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Crohn’s Disease vs. Ulcerative Colitis: What’s the Difference?

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Struggling with persistent digestive distress, unpredictable flare-ups, or exhaustion that just won’t quit can be overwhelming. For so many, these symptoms can be indicative of inflammatory bowel disease (IBD), a group of chronic gastrointestinal diseases that include Crohn’s disease and Ulcerative Colitis. Though they can seem similar on the surface — having similar symptoms of diarrhoea, abdominal pain, and weight loss — they are different in how they impact the body and how they’re treated.

Knowing the difference between ulcerative colitis and Crohn’s disease is the first step to identifying the proper care, alleviating symptoms, and taking back control of daily life. Alongside contemporary medical understanding, Ayurveda brings a distinctive, holistic approach, considering not only the disease but the individual.

In this blog, we’ll explore how these two conditions differ, what signs to watch for, and how Ayurveda approaches can help in managing them with compassion and clarity.

Difference between Ulcerative Colitis and Crohn’s disease

One of the primary distinctions between Ulcerative Colitis (UC) and Crohn’s disease (CD) lies in the location and pattern of inflammation within the digestive tract. The key differences are mentioned below

 

Feature

Ulcerative Colitis (UC)

Crohn’s Disease (CD)

Affected Region

Limited to the colon and rectum

Can affect any part of GI tract (mouth to anus)

Pattern of Inflammation

Continuous, starting from the rectum and extending proximally

Discontinuous (“skip lesions”) with healthy bowel between inflamed areas

Depth of Inflammation

Mucosal (affects only the innermost lining)

Transmural (affects all layers of the bowel wall)

Common Sites

Rectum and colon

The terminal ileum and colon are most commonly affected

Histological Features

Severe crypt distortion, decreased crypt density

Discontinuous inflammation, focal cryptitis, and non-caseating granulomas are often present

Complications

Risk of colorectal cancer, fulminant colitis, toxic megacolon

Strictures, bowel obstruction, fistulas, abscesses

Surgical Implication

Colectomy can be curative

Surgery may be needed, but it is not curative; the disease may recur elsewhere

Cancer Risk

Increased colorectal cancer risk over time

Lower cancer risk than UC, but still elevated vs. the general population

Ulcerative Colitis Symptoms

Primary symptoms:

  • Diarrhoea (frequent, may contain blood or mucus) – seen in ~95% of cases
  • Rectal bleeding – present in ~91% of cases
  • Abdominal pain or cramping
  • Tenesmus (feeling of incomplete evacuation)
  • Weight loss (due to reduced appetite and malabsorption)
  • Fever (especially during flare-ups)

Severity:

  •        Symptoms can range from mild to severe
  •        Severe cases may require hospitalisation

Extraintestinal symptoms (in ~24% of patients):

  • Joint pain
  • Skin lesions (e.g., erythema nodosum, pyoderma gangrenosum)
  • Eye inflammation (e.g., uveitis, episcleritis)
Ayurveda correlates Ulcerative Colitis symptoms with concepts like Pitta Atisara and Rakta Atisara (diarrhoea caused by vitiated pitta or blood). The disease is seen to affect the Purishavaha srotas (channels carrying faeces). Symptoms like frequent, watery, bloody or mucous stools, abdominal pain during bowel movements, tenesmus, and weight loss are described in Ayurveda texts as conditions like Pittaja Grahani (disorders of the small intestine afflicted by vitiated doshas, often pitta) and Pittaja Pravahika (dysentery of pitta origin). Pitta predominance is often linked to more severe manifestations.

Crohn’s Disease Symptoms

  • Abdominal pain, cramping, and chronic diarrhoea typically constitute Crohn’s disease manifestations.
  • Weight loss is another frequently reported symptom, afflicting approximately 93% of symptomatic patients.
  • Fatigue is a major and incapacitating symptom in 86% of cases.
  • Sleep disturbances affect around 76% of people, with problems ranging from difficulty sleeping to an urge to sleep in daytime hours.
  • Additional signs include fever, nausea, and vomiting, which tend to occur during flares.
  • Perianal disease is common in many patients and may cause pain, anal fissures, or fistulas.
  • Mouth sores may also develop in some patients.
  • The disease usually follows a flare-remission course, with symptoms ranging from mild to severe.

Crohn’s disease, being an inflammatory condition, is correlated in Ayurveda with high Pitta in the intestines and colon. It can be related to conditions like Atisara/Pittaja Atisara (diarrhoea due to high pitta), Raktatisara (diarrhoea due to vitiated blood), and Pittaja Grahani (inflammation of the small bowel due to vitiated pitta). The concept of Ashayapakarsha, where vitiated vata pulls down pitta into the colon, is also associated with inflammatory bowel conditions, including Crohn’s. 

How serious is Crohn’s disease

Crohn’s disease is a chronic condition that is treatable but can present serious complications such as diarrhoea, abdominal cramps, malnutrition, weight loss, and general fatigue. Transmural inflammation sets in, giving rise to bowel obstructions, ulcers, fistulas, abscesses, and anal fissures. Further extension of the disease can cause malnutrition, anaemia, and predispose the patient to colon carcinoma. One may also encounter extraintestinal manifestations that may affect the skin, eyes, joints, liver, gallbladder, and bones. The child’s growth and sexual development may be delayed with Crohn’s. Despite its recurrent nature, ongoing medical management and surgery are often required.

Permanent Cure for Ulcerative Colitis

Ulcerative Colitis is considered a chronic disease without a medical cure through medication alone. However, Ayurveda remedies for Ulcerative colitis aim at long-term relief by addressing the root cause through personalised diet, herbal remedies, detoxification therapies, and stress management, preventing recurrence and improving overall gut health. Adhering to the recommended diet and lifestyle is essential to prevent recurrence.

Ulcerative Colitis Treatment

Ayurveda offers comprehensive Ulcerative Colitis treatment, including Panchakarma, herbal medicines, home remedies, and diet. Ulcerative Colitis treatment in Ayurveda focuses on balancing vitiated Pitta and Vata doshas, healing intestinal ulcers (vrana shodana and ropana), and promoting bowel regularity (grahi and stambhana properties). Treatments mentioned include Vasti (enema). Piccha Vasti, a special enema, is specifically mentioned for bleeding disorders and inflammatory bowel disease with bleeding. Diet recommendations include old rice, rice washed water, liquid lentils, buttermilk, goat milk, ghee, and astringent foods like banana flowers/unripe fruit, honey, jamun, bael fruit, pomegranate, and lotus stalk. Foods to avoid include those hard to digest, high in fibre, increasing bowel motility or Pitta, alcohol, coffee, tea, milk, dried fruits, spicy food, peas, legumes, and curds. Panchakarma therapies like Pittahara vasti and Piccha Basti are used, while others like body massage and sweating therapy are generally avoided.

Crohn’s Disease Treatment

Crohn’s Disease treatment in Ayurveda focuses on managing Agni (digestive fire), digesting Ama (undigested toxins), correcting dosha imbalances (especially Pitta and Vata), and healing the gut. Treatment lines include those for Atisara (diarrhoea), Grahani (small intestine disorders), and Ashayapakarsha (displacement of doshas). Panchakarma therapies like Virechana (therapeutic purgation) are considered beneficial for expelling vitiated Pitta and preventing recurrence, ideally performed during remission. Vamana (therapeutic emesis) may be used if high Kapha is associated. Vasti (enemas) can control Vata and help rejuvenate the colon. Medicated ghrita (ghee), especially that processed with bitter herbs, is recommended for high Pitta. Rasayana (immune-modulating medicines) and Balya (strength-gaining) treatments are administered after the acute phase to prevent recurrence and support health. External therapies like Nabhi Lepa/Vasti (application/pooling around the navel) and Shirodhara/Shiro Basti (therapies on the head) help control Pitta-Vata and manage stress. Diet recommendations are similar to UC, focusing on light, digestible, astringent foods and avoiding aggravating items. Specific Ayurvedic formulations are used to enhance digestion, destroy Ama, manage diarrhoea, and support gut health.
Conclusion
While both Ulcerative Colitis and Crohn’s disease are forms of Inflammatory Bowel Disease with overlapping symptoms, they differ significantly in the location, pattern, and depth of inflammation. Both are chronic conditions requiring ongoing management. Ayurveda approaches aim to control inflammation, alleviate symptoms, and improve quality of life.

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References
Triantafyllidi, A et al. (2015). Herbal and plant therapy in patients with inflammatory bowel disease. Annals of Gastroenterology, 28, 210–220. link
Jalawadi, A R et al. (2024). AYURVEDIC MANAGEMENT OF ULCERATIVE COLITIS (PITTAJA GRAHANI): A CASE REPORT. International Journal of Research in Ayurveda and Pharmacy. link
Piparvadiya, R, P.U, S (2021). AYURVEDIYA APPROACH FOR MANAGEMENT OF ULCERATIVE COLITIS: A CASE STUDY. International Journal of Advanced Research. link
Changath, S, Soni, M (2021). Ayurvedic Management Of Ulcerative Colitis – A Case Study. International Research Journal of Ayurveda & Yoga. link
Shah, D S A et al. (2024). Ayurvedic Management of Ghrahani [Crohn’s Disease] – A Single Case Study. Journal of Advanced Zoology. link
FAQ
What is the main difference between Ulcerative Colitis and Crohn’s Disease?
Ulcerative Colitis affects only the colon lining in a continuous pattern, while Crohn's disease can affect any part of the digestive tract in segments and involves all layers of the bowel wall. This difference leads to distinct patterns of complications, such as strictures and fistulas being more common in Crohn's.
Can ulcerative colitis turn into Crohn's?
No, Ulcerative Colitis and Crohn's disease are distinct conditions, although they are both types of Inflammatory Bowel Disease. One does not transform into the other, although in some cases, differentiating between them can be difficult, leading to a diagnosis of "indeterminate colitis".
What are the 5 symptoms of Crohn's disease?
Five common symptoms of Crohn's disease include abdominal pain and cramps, diarrhoea (often chronic), fatigue, weight loss, and potential perianal disease or mouth sores. Patients may also experience fever, nausea, vomiting, or extraintestinal manifestations.
How serious is Crohn’s disease? Can Crohn's disease be cured?
Currently, there is no known cure for Crohn's disease. While treatments can significantly reduce symptoms, induce remission, and manage complications, the disease is chronic and may require ongoing therapy, including medication.

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